Is long-term use of modafinil safe?

Well supervised by a physician, long-term use of modafinil (particularly Modvigil 200) is usually regarded as quite safe, especially for diseases like narcolepsy. Studies have demonstrated sustained efficacy and tolerability over several months without tolerance or reliance. Long-term safety hasn't been completely established, yet, and prolonged usage may come with hazards including headaches, anxiety, sleeplessness, and infrequent extreme reactions (such as severe skin rash). If taken excessively or without medical supervision, several sources point to possible impacts on mood, cardiovascular stress, or sleep habits. It's important to see your doctor on a regular basis.